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Vile and co-workers have reported a practical procedure for the on-demand preparation of synthetically useful azetidinium salts via aminolysis of epichlorohydrin under continuous flow conditions. Using the Uniqsis FlowLab flow chemistry reactor system, the procedure is both simple and scalable affording high yields of products that can be isolated directly within 60 minutes at 80oC. Typically higher yields are obtained in flow than in the corresponding batch process.
了解詳情 >>The Pd-mediated reduction of o-nitrostilbenes in the presence of carbon monoxide is reported to proceed regioselectively under pressurised flow-through conditions to cleanly afford indoles. A variety of substrates are tolerated and the reaction proceeds significantly faster than in batch and produces carbon dioxide as the only stoichiometric side-product.
了解詳情 >>平推流是流動(dòng)反應(yīng)器的關(guān)鍵特性,指初始時(shí)刻進(jìn)入反應(yīng)器的任意兩個(gè)分子,將在相近時(shí)間內(nèi)流出反應(yīng)器。平推流反應(yīng)器(PFR)模型為反應(yīng)時(shí)間控制提供了有效手段,同時(shí)可優(yōu)化反應(yīng)物與產(chǎn)物的分離效果。除少數(shù)特殊應(yīng)用場(chǎng)景外,良好的平推流狀態(tài)是保障反應(yīng)器高性能的核心 —— 其意味著流體以時(shí)間有序的方式通過(guò)反應(yīng)器,且無(wú)返混現(xiàn)象。采用平推流化學(xué)技術(shù)的反應(yīng)器通常稱為平推流反應(yīng)器(PFR)。
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